Kairos Pharma (NYSE American: KAPA), a clinical-stage biopharmaceutical company focused on innovative cancer therapeutics, has entered into binding terms to acquire CL-273 from Celyn Therapeutics, Inc., a company backed by OrbiMed and Torrey Pines Investment. CL-273 is an investigational, reversible, wild-type-sparing pan-EGFR small-molecule inhibitor discovered using a proprietary AI-driven drug discovery platform and designed to target resistant mutations in EGFR-mutant non-small cell lung cancer. The EGFR-mutated lung cancer treatment market is estimated at $16.2 billion in 2026, with mutations present in approximately 10–15% of NSCLC cases in Western populations and up to 50% in Asian populations. Kairos stated the transaction is expected to be value-accretive and accelerate development of a next-generation, AI-designed EGFR inhibitor, aligning the company with OrbiMed-backed innovation. D. Boral Capital, LLC acted as sole financial advisor.
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About Kairos Pharma, Ltd.
Based in Los Angeles, California, Kairos Pharma Ltd. ( NYSE American: KAPA ) is at the forefront of oncology therapeutics, utilizing structural biology to overcome drug resistance and immune suppression in cancer. Kairos Pharma’s lead candidate, ENV-105, is an antibody that targets CD105—a protein identified as a key driver of resistance and disease relapse in response to standard therapy. ENV-105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard therapies across multiple cancer types. Currently, ENV-105 is in a Phase 2 clinical trial for castrate-resistant prostate cancer and a Phase 1 trial for non-small cell lung cancer aimed at addressing significant unmet medical needs. As of the date of this press release, ENV-105 has not been approved as safe or effective by the United States Food and Drug Administration or any other comparable foreign regulator.
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