UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
|
Washington,
D.C. 20549
|
|
SCHEDULE
TO
|
Tender
Offer Statement under Section 14(d)(1) or 13(e)(1)
of
the
Securities Exchange Act of 1934
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MEDIMMUNE,
INC.
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(Name
of Subject Company)
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ASTRAZENECA
BIOPHARMACEUTICALS INC.
ASTRAZENECA
PLC
|
(Names
of Filing Persons – Offeror)
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Common
Stock, Par Value $0.01 Per Share
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(Title
of Class of Securities)
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584699102
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(Cusip
Number of Class of Securities)
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Graeme
Musker
AstraZeneca
PLC
15
Stanhope Gate
London,
England, W1K 1LN
Telephone:
+44 20 7304 5000
|
(Name,
Address and Telephone Number of Person Authorized to Receive
Notices
and
Communications on Behalf of Filing Persons)
|
Copies
to:
|
Paul
R. Kingsley
Davis
Polk & Wardwell
450
Lexington Avenue
New
York, New York 10017
Telephone:
(212) 450-4000
|
x |
Check
the box if the filing relates solely to preliminary communications
made
before the commencement of a tender offer.
|
Check the appropriate boxes below to designate any transactions to which the statement relates: | |
x | third-party tender offer subject to Rule 14d-1. |
o | issuer tender offer subject to Rule 13e-4. |
o | going-private transaction subject to Rule 13e-3. |
o | |
Check the following box if the filing is a final amendment reporting the results of the tender offer. o |
23rd
April
2007
|
·
|
Expands
and
diversifies AstraZeneca’s science base by establishing an
international platform capable of delivering a greater flow of new
medicines in AstraZeneca’s prioritised disease areas, embracing small
molecules, monoclonal antibodies, next generation biologics and
vaccines
|
·
|
Natural
fit
between CAT and MedImmune
|
·
|
Complementary
with existing AstraZeneca therapeutic area strengths in Oncology,
Infection and Respiratory &
Inflammation
|
·
|
Provides
entry
into vaccines; through proprietary live attenuated vaccines
capability
|
·
|
Brings
significant regulatory experience in making Biologics License
Applications
|
·
|
Enhanced
biologics capability positions AstraZeneca as a more compelling licensing
partner, improving AstraZeneca’s externalisation
position
|
·
|
MedImmune
is a
leader in protein engineering and biologics manufacturing, with a
production capacity of over 30,000L planned by 2010 and world leading
cell
line productivity levels. Through further modest investment, capacity
could be increased to over 60,000L. This would secure
production requirements for the long-term and avoid the need for
major
near-term ‘green-field’ manufacturing investment by AstraZeneca to support
its biologics strategy
|
·
|
Adds
2 late-stage
assets: the next generation follow-on to ‘Synagis’, ‘Numax’ and
refrigerated formulation ‘FluMist’ with an anticipated US launch for
2007-2008 influenza season
|
·
|
Increases
the
proportion of biologics in AstraZeneca’s pipeline from 7 percent to 27
percent and enlarges the total pipeline by 45 projects to 163
projects
|
·
|
Diversifies
and expands R&D capability to deliver a greater flow of new biologic
products
|
·
|
Synergies
from
the acquisition of MedImmune and from related AstraZeneca activities
are
expected to be towards $500m per annum by
2009
|
·
|
The
acquisition is expected to be cash earnings enhancing in
2009
|
·
|
The
acquisition will be fully funded in cash, bringing improved financial
efficiency through balance sheet leverage. Previously announced $4bn
share
buyback programme for 2007
unchanged
|
·
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Addition
of
attractive marketed products including ‘Synagis’ and ‘FluMist’ to
AstraZeneca’s portfolio adds $1.2bn in sales. Consensus sales
growth for this portfolio is forecast at 12% CAGR to
2010
|
·
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Provides
AstraZeneca with several other substantial assets, including a royalty
stream on the sales of the HPV vaccines with estimated consensus
peak
sales of $5.5bn, potential milestones and royalties on MedImmune’s other
licensed products and $1.5bn cash, including $89.4m relating to MedImmune
Ventures investments at book value
|
·
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Strong
desire
to retain employees and maintain culture, with emphasis on retaining
key
talent and critical skills
|
·
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One-time
retention grant for employees
|
·
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David
M. Mott,
the Chief Executive Officer and President of MedImmune, and James
F.
Young, Ph.D., the President, Research and Development of MedImmune,
have
committed to remain with MedImmune and it is expected that other
members
of MedImmune’s senior management will stay with the company following the
closing
|
·
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David
M. Mott
will take a leadership role within
AstraZeneca
|
AstraZeneca
|
|
Media
Enquiries:
|
|
Steve
Brown /
Edel McCaffrey (London)
|
(020)
7304
5033/5034
|
Staffan
Ternby
(Sweden)
|
(8)
553
26107
|
Emily
Denney
(Wilmington)
|
(302)
885
3451
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Analyst/Investor
Enquiries:
|
|
Jonathan
Hunt
/ Mina Blair / Karl Hård (London)
|
(020)
7304
5087/5084/5322
|
Staffan
Ternby
(Sweden)
|
(8)
553
26107
|
Ed
Seage /
Jorgen Winroth (US)
|
(302)
886
4065/(212) 579 0506
|
Merrill
Lynch (Financial Adviser to AstraZeneca)
|
+44
(0) 20
7628 1000
|
Richard
Girling
|
|
Deutsche
Bank (Joint Corporate Broker to AstraZeneca)
|
+44
(0) 20
7545 8000
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Charlie
Foreman
|
|
Goldman
Sachs (Joint Corporate Broker to AstraZeneca)
|
+44
(0) 20
7774 1000
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Phil
Raper
|
|
MedImmune
|
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Media
Enquiries:
|
|
Lori
Weiman
|
240-372-4829
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Jamie
Lacey
|
301-398-4035
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Analyst/Investor
Enquiries:
|
|
Pete
Vozzo
|
301-398-4358
|
UK
freephone
|
0800
559
3272
|
US
freephone
|
+1
886
239 0753
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Sweden
freephone
|
0200
887 737
|
International
|
+44
(0)207 138 0815
|
Journalists
are invited to listen only on
|
+44
(0)207 138 0810
|
UK
freephone
|
0800
559
3271
|
US
freephone
|
+1
866
239 0765
|
Sweden
freephone
|
0200
887 740
|
International
|
+44
(0)207 806 1970
|
Replay
passcode
|
1880494#
|
AstraZeneca acquisition of MedImmune and 1Q results Analyst call |
Delivers biologics ambition faster o Creates leading, fully-integrated biologics & vaccines business o Critical mass in discovery, development, regulatory, manufacturing and sales o Natural fit with CAT o Significantly expands pipeline o Improves long term product flow o Diversifies and expands R&D (small molecules, biologics, vaccines) o Enhances future growth prospects o Profitable, high quality business entering growth phase o Cash earnings enhancement in 2009 Accelerates delivery of AZ biologics strategy at lower execution risk Transforms science base 2 |
The Deal o Fully recommended all cash offer of $58 per share; total enterprise value of $15.2bn o Transaction has been unanimously recommended by the boards of both companies. o Expected to close in June 2007 3 |
MedImmune o One of the World's Leading Biologics Players o Top 10 biopharmaceutical company by equity value o A leader in protein engineering, biologics development & manufacturing o 2006 revenues of $1.3bn o 3 marketed products, including 'blockbuster'; Synagis o Development pipeline adds 45 projects MedImmune is a scarce asset - fully integrated biologics capability, with world-class development and manufacturing, profitable and entering growth phase 4 |
Key strengths o Discovery 'Search' o Target identification and access o Highly externally focused o Well 'networked' internal venture fund (MedImmune Ventures) o Extensive and effective partnering machine o Development o Antibody generation - "create, engineer, refine" o Vaccines - proprietary live attenuated vaccine platform o Clinical - innovative, paediatrics o Regulatory - significant FDA experience (Biologic License Application) 5 |
MedImmune a recognised leader in biologics development & manufacturing Delivers high capability, scale, lowers execution risk o Production capacity of over 30,000L planned by 2010. o Significant production yield advantages o Capacity could readily be increased to over 60,000L. o Secures production requirements for the long term o Avoids near-term major `green-field' manufacturing investment by Atlanta to support its biologics strategy Rest of World Manufacturing Facility (manufacturing): Laboratory UK - Speke Vaccines Netherlands - Nijmegen 6 |
R&D capability o Expands and diversifies AstraZeneca/CAT technology base o small molecules, o monoclonal antibodies & next generation biologics o provides entry into vaccines o Externalisation/ partnering o Strengthened product pipeline o particularly in AstraZeneca's core areas of Oncology, Infection and Respiratory & Inflammation 7 |
MedImmune brings a significant pipeline o 45 projects in R&D o 7 antibody and 5 vaccine projects in clinical development o RSV next generation follow-on, Numax (2H 07 filing) o Superior potency giving possible wider utility and refreshed patent estate o Refrigerated FluMist (CAIV-T) with anticipated US launch for 2007- 2008 influenza season o Extended paediatric label under review Significant boost to the AstraZeneca pipeline, with vaccines, oncology and inflammation-targeting biologics 8 |
AZ Pipeline February 2007 AZD0530 AZD1845 AZD2327 AZD1689 AZD1080 AZD5896 AZD5904 AZD4769 AZD9056 Zactima(TM) AZD6140 Recentin(TM) (AZD2171) AZD5672 AZD1981 AZD3355 AZD2479 AZD6610 AZD6244 (ARRY- 142886) AZD1152 AZD5904 AZD0837 AZD3480 ZD4054 AZD9056 Zactima(TM) Nexium(TM) AZD2281 AZD3480 CytoFab(TM) AGI-1067 Atacand Plus(TM) AZD8797 AZD6067 AZD6370 AZD3102 AZD6357 AZD2392 AZD1744 AZD3825 AZD8931 AZD6703 AZD4121 AZD1175 AZD2207 AZD1305 AZD3783 AZD1940 AZD1236 AZD4818 AZD5069 AZD9668 AZD9215 AZD1678 AZD6605 AZD5180 AZD8330 AZD3241 AZD4877 AZD7762 AZD3646 AZD9935 AZD1283 AZD3043 AZD5861 AZD5329 Crestor/AB T-335 AZD1656 AZD3988 AZD2066 AZD2066 AZD6280 PN-400 Seroquel(TM) SR AZD1386 AZD2624 AZD0328 AZD9468 AZD2932 AZD4992 CAT-3888 CAT-8015 CAT-5001 AZD5099 AZD6918 AZD8848 AZD8075 CAT-354 CAM-3001 Seroquel(TM) SR AZD8593 Saxagliptin Dapaglifloz in AZD9272 New Since Feb 2006 No change AZD3199 AZD7903 Progression AZD0424 AZD9684 AZD6538 AZD7928 Nexium(TM) Seloken(TM)/ Toprol XL (TM) Crestor(TM) Crestor(TM) Crestor(TM) Nexium(TM) Nexium(TM) Seroquel(TM) Symbicort (TM) pMDI Symbicort (TM) Turbuhaler (TM) Symbicort (TM) pMDI Iressa(TM) Seroquel(TM) Seroquel(TM) SR Atacand(TM) Nexium(TM) Seroquel(TM) SR Seroquel(TM) SR Nexium(TM) Faslodex(TM) Faslodex(TM) Pre-Clinical Phase I Phase II LCM Phase III MedImmune PC 9 |
AZD0530 AZD1845 AZD2327 AZD1080 AZD5896 AZD5904 AZD4769 AZD9056 Zactima(TM) Recentin(TM) (AZD2171) AZD5672 AZD1981 AZD3355 AZD6610 AZD6244 (ARRY- 142886) AZD1152 AZD5904 AZD0837 AZD3480 ZD4054 AZD9056 Zactima(TM) Nexium(TM) AZ Pipeline incorporating MedImmune AZD2281 AZD3480 CytoFab(TM) AZD6140 Atacand Plus(TM) AZD8797 AZD6067 AZD6370 AZD3102 AZD6357 AZD2392 AZD1744 AZD3825 AZD8931 AZD6703 AZD4121 AZD1175 AZD2207 AZD1305 AZD3783 AZD1940 AZD1236 AZD4818 AZD5069 AZD9668 AZD9215 AZD1678 AZD6605 AZD5180 AZD8330 AZD3241 AZD4877 AZD7762 AZD3646 AZD9935 AZD1283 AZD3043 AZD5861 AZD5329 Crestor/AB T-335 AZD1656 AZD3988 AZD2066 AZD2066 AZD6280 PN-400 Seroquel(TM) SR AZD1386 AZD2624 AZD0328 AZD9468 AZD2932 AZD4992 CAT-3888 CAT-8015 CAT-5001 AZD5099 AZD6918 AZD8848 AZD8075 CAT-354 CAM-3001 Seroquel(TM) SR AZD8593 Saxagliptin Dapaglifloz in AZD9272 New Since Feb 2006 No change AZD3199 AZD7903 Progression AZD0424 AZD6538 AZD7928 Nexium(TM) Seloken(TM)/ Toprol XL (TM) Crestor(TM) Crestor(TM) Crestor(TM) Nexium(TM) Nexium(TM) Seroquel(TM) Symbicort (TM) pMDI Symbicort (TM) Turbuhaler (TM) Symbicort (TM) pMDI Iressa(TM) Seroquel(TM) Seroquel(TM) SR Atacand(TM) Nexium(TM) Seroquel(TM) SR Seroquel(TM) SR Nexium(TM) Faslodex(TM) Faslodex(TM) AZ Pre-Clinical Phase I Phase II LCM Phase III MedImmune PC Numax Anti-IL9 MAb Anti-IFNa MAb Anti-IL5R MAb Anti- HMGB-1 MAb Anti-CD22 MAb Anti-CD20 MAb Anti-CD19 MAb Anti-IFNaR MAb Siplizumab Anti-CD19 BiTE Hsp 90 inhibitor Anti-cMet Avimers Anti-ALK MAb Anti-CD22 MAb Anti-CD20 MAb Anti-CD19 MAb Anti-EphA4 MAb Anti-Ephrin B2 MAb Anti-EphB4 MAb Anti- EphA2 BiTE Hedgehog inhibitor Anti-EphA2 conjugate ZD4054 EBV vaccine Pneumoco ccal vac PIV-3 vaccine RSV /PIV- 3 vaccine hMPV/ PIV-3 vac H5N1 vaccine 3rd gen RSV MAb Anti-RSV drug hMPV vaccine Anti-staph HP MAb FluMist (CAIV-T) Medimmune Med Partnered Synagis Anti- Chitinase MAb AZD2836 hMPV MAb Plus a further 7 early preclinical 10 |
AZD0530 AZD1845 AZD2327 AZD2836 AZD1080 AZD5896 AZD5904 AZD4769 AZD9056 Zactima(TM) AZD6140 Recentin(TM) (AZD2171) AZD5672 AZD1981 AZD3355 AZD6610 AZD6244 (ARRY- 142886) AZD1152 AZD5904 AZD0837 AZD3480 ZD4054 AZD9056 Zactima(TM) Nexium(TM) AZ Pipeline incorporating MedImmune AZD2281 AZD3480 CytoFab(TM) Atacand Plus(TM) AZD8797 AZD6067 AZD6370 AZD3102 AZD6357 AZD2392 AZD1744 AZD3825 AZD8931 AZD6703 AZD4121 AZD1175 AZD2207 AZD1305 AZD3783 AZD1940 AZD1236 AZD4818 AZD5069 AZD9668 AZD9215 AZD1678 AZD6605 AZD5180 AZD8330 AZD3241 AZD4877 AZD7762 AZD3646 AZD9935 AZD1283 AZD3043 AZD5861 AZD5329 Crestor/AB T-335 AZD1656 AZD3988 AZD2066 AZD2066 AZD6280 PN-400 Seroquel(TM) SR AZD1386 AZD2624 AZD0328 AZD9468 AZD2932 AZD4992 CAT-3888 CAT-8015 CAT-5001 AZD5099 AZD6918 AZD8848 AZD8075 CAT-354 CAM-3001 Seroquel(TM) SR AZD8593 Saxagliptin Dapaglifloz in AZD9272 Biologicals AZD3199 AZD7903 Small Molecules AZD0424 AZD6538 AZD7928 Nexium(TM) Seloken(TM)/ Toprol XL (TM) Crestor(TM) Crestor(TM) Crestor(TM) Nexium(TM) Nexium(TM) Seroquel(TM) Symbicort (TM) pMDI Symbicort (TM) Turbuhaler (TM) Symbicort (TM) pMDI Iressa(TM) Seroquel(TM) Seroquel(TM) SR Atacand(TM) Nexium(TM) Seroquel(TM) SR Seroquel(TM) SR Nexium(TM) Faslodex(TM) Faslodex(TM) AZ Pre-Clinical Phase I Phase II LCM Phase III MedImmune PC Numax Anti-IL9 MAb Anti-IFNa MAb Anti-IL5R MAb Anti- HMGB-1 MAb Anti-CD22 MAb Anti-CD20 MAb Anti-CD19 MAb Anti-IFNaR MAb Siplizumab Anti-CD19 BiTE Hsp 90 inhibitor Anti-cMet Avimers Anti-ALK MAb Anti-CD22 MAb Anti-CD20 MAb Anti-CD19 MAb Anti-EphA4 MAb Anti-Ephrin B2 MAb Anti-EphB4 MAb Anti- EphA2 BiTE Hedgehog inhibitor Anti-EphA2 conjugate ZD4054 EBV vaccine Pneumoco ccal vac PIV-3 vaccine RSV /PIV- 3 vaccine hMPV/ PIV- 3 vac H5N1 vaccine 3rd gen RSV MAb Anti-RSV drug hMPV MAb hMPV vaccine Anti-staph HP MAb FluMist (CAIV-T) Synagis Anti- Chitinase MAb Plus a further 7 early preclinical 11 |
R&D Summary o Adds 2 late stage assets o Synagis next generation follow-on Numax o refrigerated formulation FluMist o Increases the proportion of biologics in AZ pipeline from 7% to 27% o Enlarges the total pipeline by 45 projects to 163 projects o Diversifies and expands R&D capability (small molecules, biologics, vaccines) to deliver a greater flow of new products 12 |
Financials |
Headline results 1Q 07 2007 2006 Actual CER $m $m growth growth Sales 6,966 6,180 +13% +9% Operating profit 2,170 1,976 +10% +10% Reported EPS $1.02 $0.90 +13% +14% Restructuring $0.04 - Toprol XL ($0.13) ($0.11) Adjusted EPS $0.93 $0.79 14 |
Q1 2007 P&L CER Q1 07 growth Comment Sales $6,966m +9% Gross Profit $5,480m 78.7% $82m restructuring; $24m AGI 1067 provision. Underlying +0.7pts R&D $1,170m +26% $69m intangibles write-off SG&A $2,217m --- Other Income $138m Lower royalties; insurance recoveries 15 |
2007 Outlook o On-track to achieve 2007 target o EPS range $3.80 - $4.05 (excl. Toprol XL & Restructuring costs) o Q1 Toprol XL $0.13 / approx. $100m/month o Q1 Restructuring $82m ($0.04), ~$250m in 2007 16 |
1Q 2007 sales: Key Growth Drivers Sales CER $m % growth Nexium(R) 1,308 +8% Seroquel(R) 923 +13% Crestor(R) 628 +59% Arimidex(R) 401 +15% Symbicort(R) 354 +19% Total 3,614 +17% 17 |
MedImmune acquisition o $58 per share o Total enterprise value $15.2bn o Financing o $15bn bridge o AZ cash o Refinance with package of debt with varying maturities o Balance sheet geared o 2007 buyback confirmed ($4bn) o Dividend policy unchanged 18 |
Acquisition impact o Accelerates biologics strategy o Financial synergies o Reduced execution risk o MedImmune is a growing business o Global Sales and Marketing leverage o Accretive to cash EPS in 2009 o Synergy potential of ~$500m per annum by 2009 o Annual amortisation ~$750m 19 |
People o Strong desire to retain employees and maintain culture, with emphasis on retaining key talent and critical skills o One-time retention grant for employees o Significantly increases AstraZeneca's skills and capabilities in development and manufacture of biologics & vaccines o Strong external collaboration/partnering skills o David M Mott to take leadership role in AstraZeneca o James F Young committed to remain in current role High quality people; who combine strong science skills with strong business skills 20 |
Delivers biologics ambition faster o Creates leading, fully-integrated biologics and vaccines business o Significantly expands pipeline o Enhances future growth prospects Accelerates delivery of AZ biologics strategy at lower execution risk Transforms science base 21 |
Additional Information PRESENTATION DISCLAIMER o The tender offer described in this presentation has not yet commenced, and this presentation is neither an offer to purchase nor a solicitation of an offer to sell MedImmune common stock. Investors and security holders are urged to read both the tender offer statement and the solicitation/recommendation statement regarding the tender offer described in this presentation when they become available because they will contain important information. The tender offer statement will be filed by AstraZeneca and a subsidiary of AstraZeneca with the Securities and Exchange Commission (SEC), and the solicitation/recommendation statement will be filed by MedImmune with the SEC. Investors and security holders may obtain a free copy of these statements (when available) and other documents filed by AstraZeneca or MedImmune with the SEC at the website maintained by the SEC at www.sec.gov. The tender offer statement and related materials may be obtained for free by directing such requests to AstraZeneca (Investor Relations) at +44 (0) 207 304 5000. The solicitation/recommendation statement and such other documents may be obtained by directing such requests to MedImmune (Investor Relations) at 301 398 4358. o Copies of this presentation and any documentation relating to the Offer are not being, and must not be, directly or indirectly, mailed or otherwise forwarded, distributed or sent in or into or from Canada, Japan or Australia or any other jurisdiction where to do so would be unlawful. o This presentation may contain certain forward-looking statements about AstraZeneca and MedImmune which are subject to risks and uncertainties and may be influenced by factors that could cause actual outcomes and results to be materially different from those predicted. We have identified the forward-looking statements by using the words `anticipates', `believes', `expects', `intends' and similar expressions in such statements. Important factors that could cause actual results to differ materially from those contained in forwardlooking statements, certain of which are beyond our control, include, among other things: difficulties in integrating MedImmune leading to greater costs and lower integration benefits than we anticipate; regulatory conditions being imposed on the acquisition of MedImmune; patent litigation and early loss or expiration of patents, marketing exclusivity or trade marks; substantial adverse outcomes of litigation and government litigation; exchange rate fluctuations; the risk that R&D will not yield new products that achieve commercial success; the impact of competition, price controls and price reductions; taxation risks; the risk of substantial product liability claims; the impact of any failure by third parties to supply materials or services; the risk of delay to new product launches; the difficulties of obtaining and maintaining governmental approvals for products; the risk of failure to observe ongoing regulatory oversight; the risk that new products do not perform as we expect; and the risk of environmental liabilities. For further discussion of factors that may cause actual results to differ from expectations, you should read AstraZeneca's most recent UK Annual Report and MedImmune's most recent regulatory filings and submissions, including the Annual Reports on Form 20-F and Form 10-K of AstraZeneca and MedImmune, respectively. You are cautioned not to place undue reliance on any forward-looking statements, which speak only as of the date of this presentation. Except as required by applicable law or regulation, AstraZeneca and MedImmune do not undertake any obligation to publicly release any update or revisions to these forward-looking statements. 22 |