UNITED STATES
                    SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C. 20549

                                SCHEDULE 13G

                 Under the Securities Exchange Act of 1934
                          (Amendment No.       )*
                                         ------

                            Cubist Pharmaceuticals
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                              (Name of Issuer)

                                   Common
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                       (Title of Class of Securities)

                                 229678107
                     ----------------------------------
                              (CUSIP Number)

                                  12/31/00
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               (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

     /X/ Rule 13d-1(b)

     / / Rule 13d-1(c)

     / / Rule 13d-1(d)

   *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.

   The information required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that
section of the Act but shall be subject to all other provisions of the Act
(however, see the Notes).



CUSIP No. 229678107
          ---------

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 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

     Hambrecht & Quist Capital Management 943021090
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 (2) Check the Appropriate Box if a Member   (a)  / /
     of a Group (See Instructions)           (b)  /X/
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 (3) SEC Use Only

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 (4) Citizenship or Place of Organization
     California Corp.
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 Number of Shares             (5) Sole Voting Power
 Beneficially                     958,005
 Owned by                    --------------------------------------------------
 Each Reporting               (6) Shared Voting Power
 Person With:
                             --------------------------------------------------
                              (7) Sole Dispositive Power

                             --------------------------------------------------
                              (8) Shared Dispositive Power

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 (9) Aggregate Amount Beneficially Owned by Each Reporting Person
     958,005
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(10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
     Instructions)        / /
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(11) Percent of Class Represented by Amount in Row (9)
     3.53
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(12) Type of Reporting Person (See Instructions)
     IA
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ITEM 1.

    (a)   Name of Issuer
          Cubist Pharmaceuticals
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    (b)   Address of Issuer's Principal Executive Offices
          24 Emily Street
          Cambridge, MA 02139
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ITEM 2.

    (a)   Name of Person Filing
          Hambrecht & Quist Capital Management Incorporated
          ---------------------------------------------------------------------
    (b)   Address of Principal Business Office or, if none, Residence
          30 Rowes Wharf - 4th Floor
          Boston, MA 02110-3328
          ---------------------------------------------------------------------
    (c)   Citizenship
          (California Corporation)
          ---------------------------------------------------------------------
    (d)   Title of Class of Securities
          Common stock
          ---------------------------------------------------------------------
    (e)   CUSIP Number
          229678107
          ---------------------------------------------------------------------

ITEM 3.  IF THIS STATEMENT IS FILED PURSUANT TO SECTIONS 240.13d-1(b) OR
         240.13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

    (a) / / Broker or dealer registered under section 15 of the Act
            (15 U.S.C. 78o).

    (b) / / Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

    (c) / / Insurance company as defined in section 3(a)(19) of the Act
            (15 U.S.C. 78c).

    (d) / / Investment company registered under section 8 of the Investment
            Company Act of 1940 (15 U.S.C. 80a-8).

    (e) /X/ An investment adviser in accordance with section
            240.13d-1(b)(1)(ii)(E).

    (f) / / An employee benefit plan or endowment fund in accordance with
            section 240.13d-1(b)(1)(ii)(F).

    (g) / / A parent holding company or control person in accordance with
            section 240.13d-1(b)(1)(ii)(G).

    (h) / / A savings association as defined in section 3(b) of the Federal
            Deposit Insurance Act (12 U.S.C. 1813).

    (i) / / A church plan that is excluded from the definition of an investment
            company under section 3(c)(14) of the Investment Company Act of 1940
            (15 U.S.C. 80a-3).

    (j) / / Group, in accordance with section 240.13d-1(b)(1)(ii)(J).




ITEM 4.  OWNERSHIP

    Hambrecht & Quist Capital Management Incorporated ("HQCM") disclaims any
beneficial interest in the shares reported in this Schedule 13G. Moreover,
HQCM is of the view that the client accounts that it manages are not acting
as a "group" for purposes of Section 13(d) under the Securities and Exchange
Act of 1934 (the "1934 Act") and that it and such clients are not otherwise
required to attribute to each other the "beneficial ownership" of securities
"beneficially owned" under Rule 13d-3 promulgated under the 1934 Act.
Therefore, HQCM is of the view that the shares held in such accounts should
not be aggregated for purposes of Section 13(d). However, HQCM is making this
filing on a voluntary basis as if all the shares are beneficially owned by
HQCM on a joint basis.

    (a) Amount beneficially owned:
        958,005
    ---------------------------------------------------------------------------

    (b) Percent of class:
        3.53% of Common
    ---------------------------------------------------------------------------

    (c) Number of shares as to which the person has:

          (i) Sole power to vote or to direct the vote
              958,005
              -----------------------------------------------------------------
         (ii) Shared power to vote or to direct the vote

              -----------------------------------------------------------------
        (iii) Sole power to dispose or to direct the disposition of
              958,005
              -----------------------------------------------------------------
         (iv) Shared power to dispose or to direct the disposition of

              -----------------------------------------------------------------


ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

    If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following.  /X/


ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

    N/A

ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
         THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

    N/A

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

    N/A

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP

    N/A




ITEM 10. CERTIFICATION


    By signing below I certify that, to the best of my knowledge and belief,
    the securities referred to above were acquired in the ordinary course of
    business and were not acquired for the purpose of and do not have the
    effect of changing or influencing the control of the issuer of such
    securities and were not acquired in connection with or as a participant
    in any transaction having such purposes or effect.

                                  SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                                        1/23/01
                                       ----------------------------------------
                                                         Date

                                                   /s/ Kim Carroll
                                       ----------------------------------------
                                                      Signature

                                       Kim Carroll, Vice President
                                       Hambrecht & Quist Capital Management
                                       Incorporated
                                       ----------------------------------------
                                                      Name/Title