SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                ----------------

                                  SCHEDULE 13G
                                 (Rule 13d-102)
                                ----------------

    INFORMATION TO BE INCLUDED IN STATEMENTS PURSUANT TO RULES 13d-1(b), (c)
             AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934



                                   NUVELO INC.
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)

                                    67072M103
                                 (CUSIP Number)

                                  July 18, 2003
             (Date of Event Which Requires Filing of this Statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
     [ ] Rule 13d-1(b)
     [X] Rule 13d-1(c)
     [ ] Rule 13d-1(d)


-----------


     The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).





Schedule 13G                                                     PAGE 2 OF 14

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1) NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
              CLSP, L.P.
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                  (a) [x]
                                                                  (b) [ ]
-----------------------------------------------------------------------------
     (3) SEC USE ONLY

-----------------------------------------------------------------------------
     (4) CITIZENSHIP OR PLACE OF ORGANIZATION
               Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,323,180
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,323,180
-----------------------------------------------------------------------------
     (9) AGGREGATE AMOUNT BENEFICIALLY OWNED
         BY EACH REPORTING PERSON
              1,323,180
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
         IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11) PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (9)
             2.1%
-----------------------------------------------------------------------------
    (12) TYPE OF REPORTING PERSON
             PN
-----------------------------------------------------------------------------




Schedule 13G                                                     PAGE 3 OF 14

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1) NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
              CLSP II, L.P.
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a) [x]
                                                                 (b) [ ]
-----------------------------------------------------------------------------
     (3) SEC USE ONLY

-----------------------------------------------------------------------------
     (4) CITIZENSHIP OR PLACE OF ORGANIZATION
              Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,103,403
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,103,403
-----------------------------------------------------------------------------
     (9) AGGREGATE AMOUNT BENEFICIALLY OWNED
         BY EACH REPORTING PERSON
              1,103,403
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
         IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11) PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (9)
               1.7%
-----------------------------------------------------------------------------
    (12) TYPE OF REPORTING PERSON
              PN
-----------------------------------------------------------------------------




Schedule 13G                                                     PAGE 4 OF 14

CUSIP No. 67073M103
-----------------------------------------------------------------------------
     (1) NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
              CLSP/SBS I, L.P.
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                   (a) [x]
                                                                   (b) [ ]
-----------------------------------------------------------------------------
     (3) SEC USE ONLY

-----------------------------------------------------------------------------
     (4) CITIZENSHIP OR PLACE OF ORGANIZATION
              Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    493,533
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    493,533
-----------------------------------------------------------------------------
     (9) AGGREGATE AMOUNT BENEFICIALLY OWNED
         BY EACH REPORTING PERSON
              493,533
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
         IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11) PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (9)
              0.8%
-----------------------------------------------------------------------------
    (12) TYPE OF REPORTING PERSON
              PN
-----------------------------------------------------------------------------




Schedule 13G                                                     PAGE 5 OF 14

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1) NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         CLSP/SBS II, L.P.
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [x]
                                                                    (b) [ ]
-----------------------------------------------------------------------------
     (3) SEC USE ONLY

-----------------------------------------------------------------------------
     (4) CITIZENSHIP OR PLACE OF ORGANIZATION
              Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    169,801
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    169,801
-----------------------------------------------------------------------------
     (9) AGGREGATE AMOUNT BENEFICIALLY OWNED
         BY EACH REPORTING PERSON
              169,801
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
         IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11) PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (9)
              0.3%
-----------------------------------------------------------------------------
    (12) TYPE OF REPORTING PERSON
              PN
-----------------------------------------------------------------------------




Schedule 13G                                                     PAGE 6 OF 14

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1) NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
              Cooper Hill Partners, L.P.
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [x]
                                                                    (b) [ ]
-----------------------------------------------------------------------------
     (3) SEC USE ONLY

-----------------------------------------------------------------------------
     (4) CITIZENSHIP OR PLACE OF ORGANIZATION
              Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    947,941
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    947,941
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
               947,941
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
         IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11) PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (9)
              1.5%
-----------------------------------------------------------------------------
    (12) TYPE OF REPORTING PERSON
              PN
-----------------------------------------------------------------------------




Schedule 13G                                                     PAGE 7 OF 14

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1) NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
              Cooper Hill Partners, LLC
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [x]
                                                                    (b) [ ]
-----------------------------------------------------------------------------
     (3) SEC USE ONLY

-----------------------------------------------------------------------------
     (4) CITIZENSHIP OR PLACE OF ORGANIZATION
              Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    3,089,917
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    3,089,917
-----------------------------------------------------------------------------
     (9) AGGREGATE AMOUNT BENEFICIALLY OWNED
         BY EACH REPORTING PERSON
              3,089,917
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
         IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11) PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (9)
               4.9%
    (12) TYPE OF REPORTING PERSON
               OO
-----------------------------------------------------------------------------





Schedule 13G                                                     PAGE 8 OF 14

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1) NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
              Jeffrey Casdin
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [x]
                                                                    (b) [ ]
-----------------------------------------------------------------------------
     (3) SEC USE ONLY

-----------------------------------------------------------------------------
     (4) CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                         4,037,858
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                         4,037,858
-----------------------------------------------------------------------------
     (9) AGGREGATE AMOUNT BENEFICIALLY OWNED
         BY EACH REPORTING PERSON
              4,037,858
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
         IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11) PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (9)
              6.3%
-----------------------------------------------------------------------------
    (12) TYPE OF REPORTING PERSON
              IN
-----------------------------------------------------------------------------







Schedule 13G                                                     PAGE 9 OF 14

ITEM 1(a).  NAME OF ISSUER:
             NUVELO INC.

ITEM 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
             675 Almanor Avenue Sunnyvale, CA 94085

ITEM 2(a).  NAME OF PERSON FILING:

     This statement is filed by:
          (i) CLSP, L.P. ("CLSP"),
              a Delaware limited partnership, with respect to the Securities
              owned by it;
         (ii) CLSP II, L.P. ("CLSP II") a Delaware limited partnership, with
              respect to the Securities owned by it;
        (iii) CLSP/SBS I, L.P. ("CLSP/SBS I") a Delaware limited partnership,
              with respect to the Securities owned by it;
         (iv) CLSP/SBS II, L.P. ("CLSP/SBS II") a Delaware limited partnership,
              with respect to the Securities owned by it;
          (v) Cooper Hill Partners, L.P., a Delaware limited partnership with
              respect to the Securities held for CLSP Overseas, Ltd. ("CLSP
              Overseas"), a Cayman Islands exempted company;
         (vi) Cooper Hill Partners, LLC ("Cooper, LLC "), a Delaware limited
              liability company and the sole general partner of CLSP, CLSP II,
              CLSP/SBS I AND CLSP/SBS II with respect to the Securities owned by
              CLSP, CLSP II, CLSP/SBS I AND CLSP/SBS II; and
        (vii) Jeffrey Casdin a citizen of the United States, and the Managing
              Member of Casdin Capital, LLC, the general partner of Cooper Hill
              Partners, L.P. and the managing member of Cooper LLC, with respect
              to Securities subject to the control of Cooper LLC and Cooper Hill
              Partners, LP.

              The foregoing persons (other than CLSP Overseas) are hereinafter
              sometimes collectively referred to as the "Reporting Persons." Any
              disclosures herein with respect to persons other than the
              Reporting Persons are made on information and belief after making
              inquiry to the appropriate party.





Schedule 13G                                                   PAGE 10 OF 14

ITEM 2(b).  ADDRESS OF PRINCIPAL OFFICE OR, IF NONE, RESIDENCE:
            The business address of each of the Reporting Persons is 230 Park
Avenue, New York, New York 10169. The business address of CLSP Overseas is c/o
Goldman Sachs (Cayman) Trust, Limited P.O. Box 896 G.T. Harbour Centre, Second
Floor, North Church Street, George Town, Grand Cayman, Cayman Islands, B.W.I.

ITEM 2(c).  CITIZENSHIP:
             Cooper Hill Partners, LLC is a Delaware limited liability company
and CLSP, CLSP II, CLSP/SBS I, CLSP/SBS II and Cooper Hill Partners, L.P. are
each a Delaware limited partnership. CLSP Overseas is a Cayman Islands exempted
company. Jeffrey Casdin is a citizen of the United States.

ITEM 2(d).  TITLE OF CLASS OF SECURITIES: Common Stock, $.01 par value

ITEM 2(e).  CUSIP NUMBER:                 67072M103

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO 13d-1(b) OR 13d-2(b) OR (c),
CHECK WHETHER THE PERSON FILING IS A:

          (a)    [ ] Broker or dealer registered under Section 15 of the Act

          (b)    [ ] Bank as defined in Section 3(a)(6) of the Act

          (c)    [ ] Insurance Company as defined in Section 3(a)(19) of the
                     Act

          (d)    [ ] Investment Company registered under Section 8 of the
                     Investment Company Act of 1940

          (e)    [ ] Investment Adviser registered under Section 203 of the
                     Investment Advisers Act of 1940: see Rule 13d-
                     1(b)(1)(ii)(E)

          (f)    [ ] Employee Benefit Plan, Pension Fund which is subject to
                     the provisions of the Employee Retirement Income Security
                     Act of 1974 or Endowment Fund; see Rule 13d- 1(b)(1)(ii)(F)

          (g)    [ ] Parent Holding Company, in accordance with Rule 13d-
                     1(b)(ii)(G);

          (h)    [ ] Savings Associations as defined in Section 3(b) of the
                     Federal Deposit Insurance Act;

          (i)    [ ] Church Plan that is excluded from the definition of an
                     investment company under Section 3(c)(14) of the Investment
                     Company Act of 1940;



Schedule 13G                                                    PAGE 11 OF 14

          (j)    ( ) Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

         IF THIS STATEMENT IS FILED PURSUANT TO Rule 13d-1(c), CHECK THIS
BOX. [x]


ITEM 4.   OWNERSHIP.
     A.  CLSP
        (a) Amount beneficially owned: 1,323,180
        (b) Percent of class: 2.1% (All percentages herein are based on
            63,667,334 shares of Common Stock reported to be outstanding as of
            June 30, 2003, as reflected in the Company's quarterly report on
            Form S-3 filed with the Securities and Exchange Commission by the
            Company on July 8, 2003.)
        (c) Number of shares as to which such person has:
             (i)    sole power to vote or to direct the vote
                    0
             (ii)   shared power to vote or to direct the vote
                    1,323,180
             (iii)  sole power to dispose or to direct the disposition of
                    0
             (iv)   shared power to dispose or to direct the disposition of
                    1,323,180

B. CLSP II
        (a) Amount beneficially owned: 1,103,403
        (b) Percent of class: 1.7%
        (c) Number of shares as to which such person has:
             (i)    sole power to vote or to direct the vote
                    0
             (ii)   shared power to vote or to direct the vote
                    1,103,403
             (iii)  sole power to dispose or to direct the disposition of
                    0
             (iv)   shared power to dispose or to direct the disposition of
                    1,103,403

     C. CLSP/SBS I
        (a) Amount beneficially owned: 493,533
        (b) Percent of class: 0.8%
        (c) Number of shares as to which such person has:
             (i)    sole power to vote or to direct the vote
                    0
             (ii)   shared power to vote or to direct the vote
                    493,533
             (iii)  sole power to dispose or to direct the disposition of
                    0




  Schedule 13G                                                    PAGE 12 OF 14

             (iv)   shared power to dispose or to direct the disposition of
                    493,533

     D. CLSP/SBS II
        (a) Amount beneficially owned: 169,801
        (b) Percent of class: 0.3%
        (c) Number of shares as to which such person has:
             (i)    sole power to vote or to direct the vote
                    0
             (ii)   shared power to vote or to direct the vote
                    169,801
             (iii   sole power to dispose or to direct the disposition of
                    0
             (iv)   shared power to dispose or to direct the disposition of
                    169,801

     E. Cooper Hill Partners, L.P.
        (a) Amount beneficially owned: 947,941
        (b) Percent of class: 1.5%
        (c) Number of shares as to which such person has:
             (i)    sole power to vote or to direct the vote
                    0
             (ii)   shared power to vote or to direct the vote
                    947,941
             (iii)  sole power to dispose or to direct the disposition
                    of 0
             (iv)   shared power to dispose or to direct the disposition
                    of 947,941

     F. Cooper Hill Partners, LLC
        (a) Amount beneficially owned: 3,089,917
        (b) Percent of class: 4.9%
        (c) Number of shares as to which such person has:
             (i)    sole power to vote or to direct the vote
                    0
             (ii)   shared power to vote or to direct the vote
                    3,089,917
             (iii)  sole power to dispose or to direct the disposition
                    of 0
             (iv)   shared power to dispose or to direct the disposition
                    of 3,089,917




Schedule 13G                                                    PAGE 13 OF 14

     G.  Jeffrey Casdin
        (a) Amount beneficially owned: 4,037,858
        (b) Percent of class: 6.3%
        (c) Number of shares as to which such person has:
             (i)    sole power to vote or to direct the vote
                    0
             (ii)   shared power to vote or to direct the vote
                    4,037,858
             (iii)  sole power to dispose or to direct the disposition
                    of 0
             (iv)   shared power to dispose or to direct the disposition
                    of 4,037,858

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
         IF THIS STATEMENT IS BEING FILED TO REPORT THE FACT THAT AS OF THE
         DATE HEREOF THE REPORTING PERSON HAS CEASED TO BE THE BENEFICIAL OWNER
         OF MORE THAN 5% OF THE CLASS OF SECURITIES CHECK THE FOLLOWING [ ].

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

     CLSP, CLSP II, CLSP/SBS I, and CLSP/SBS II are each private investment
partnerships, the sole general partner of which is Cooper, LLC. As the sole
general partner of CLSP, CLSP II, CLSP/SBS I, and CLSP/SBS II, Cooper, LLC has
the power to vote and dispose of the Securities owned by each of CLSP, CLSP II,
CLSP/SBS I, and CLSP/SBS II and, accordingly, may be deemed the "beneficial
owner" of such Securities. The managing member of Cooper, LLC is Jeffrey Casdin.

     Pursuant to an investment advisory contract, Cooper Hill Partners, L.P.
currently has the power to vote and dispose of the Securities held for the
account of CLSP Overseas, Ltd. and, accordingly, may be deemed the "beneficial
owner" of such Securities. Mr. Casdin is the managing member of Casdin Capital,
LLC, the general partner of Cooper Hill Partners, L.P.


ITEM 7.   IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
          THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.
          Not applicable.

ITEM 8.   IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
          See Item 6.

ITEM 9.   NOTICE OF DISSOLUTION OF GROUP.
          Not applicable.




Schedule 13G                                                   PAGE 14 OF 14

ITEM 10.  CERTIFICATION.  (if filing pursuant to Rule 13d-1(c))

         Each of the Reporting Persons and CLSP Overseas, Ltd. hereby make the
following certification:

         By signing below each Reporting Person certifies that, to the best of
its knowledge and belief, the securities referred to above were not acquired and
are not held for the purpose of or with the effect of changing or influencing
the control of the issuer of the Securities and were not acquired and not held
in connection with or as a participant in any transaction having that purpose or
effect.


                                   SIGNATURES

         After reasonable inquiry and to the best of our knowledge and belief,
the undersigned certify that the information set forth in this statement is
true, complete and correct.

DATED:                              /s/ Jeffrey Casdin,
                                    JEFFREY CASDIN, individually,and
                                    as managing member of Cooper Hill
                                    Partners, LLC, and on behalf of CLSP,
                                    L.P., CLSP II, L.P., CLSP/SBS I, L.P.,
                                    and CLSP/SBS II, L.P. and as managing
                                    member of Casdin Capital, L.L.C., the
                                    general partner of Cooper Hill Partners,
                                    L.P.