UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                   FORM 13F

                             FORM 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: December 31, 2005

Check here if Amendment [ ]; Amendment Number:
This Amendment (Check only one.): [ ] is a restatement.
                                  [ ] adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:GENERAL AMERICAN INVESTORS COMPANY, INC.
Address: 450 Lexington Ave, Suite 3300
         New York, NY 10017

13F File Number: 28-461

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:

Name: Eugene S. Stark
Title: Vice-President, Administration
Phone: 212-916-8447
Signature, Place, and Date of Signing:

  Eugene S. Stark   New York, NY   February 9, 2006


Report Type (Check only one.):

[X]    13F HOLDINGS REPORT.

[ ]    13F NOTICE.

[ ]    13F COMBINATION REPORT.



                              FORM 13F SUMMARY PAGE


Report Summary:

Number of Other Included Managers:       0

Form 13F Information Table Entry Total:  57

Form 13F Information Table Value Total:  $1287580900



List of Other Included Managers:

NONE




   COLUMN 1                           COLUMN 2     COLUMN 3  COLUMN 4      COLUMN 5    COLUMN 6  COLUMN 7         COLUMN 8
 --------------                      ---------    ---------  -------- -------------    --------  --------    ------------------
                                                             VALUE    SHARES/ SH/ PUT/ INVSTMT   OTHER    -----VOTING AUTHORITY-----
  NAME OF ISSUER                 -TITLE OF CLASS- --CUSIP-- x$1000    PRN AMT PRN CALL DSCRETN -MANAGERS-     SOLE   SHARED     NONE
                                                                                                      
Arch Capital Group Ltd.          COMMON           G0450A105    19163   350000 SH       SOLE                 350000        0        0
Adams Express Company            COMMON           006212104     1319   105075 SH       SOLE                 105075        0        0
American International Group,Inc COMMON           026874107    23539   345000 SH       SOLE                 345000        0        0
Alkermes, Inc.                   COMMON           01642T108     5067   265000 SH       SOLE                 265000        0        0
The Allstate Corporation         COMMON           020002101     9192   170000 SH       SOLE                 170000        0        0
American Tower Corporation       COMMON           029912201    18293   675000 SH       SOLE                 675000        0        0
Annuity and Life Re (Holdings),  COMMON           G03910109      575   500000 SH       SOLE                 500000        0        0
Apache Corporation               COMMON           037411105    45566   665000 SH       SOLE                 665000        0        0
Bank of America Corporation      COMMON           060505104    12922   280000 SH       SOLE                 280000        0        0
Bed Bath & Beyond Inc.           COMMON           075896100     7230   200000 SH       SOLE                 200000        0        0
Bancroft Convertible Fund        COMMON           059695106      386    21374 SH       SOLE                  21374        0        0
Biogen Idec Inc.                 COMMON           09062X103     8150   180000 SH       SOLE                 180000        0        0
Berkshire Hathaway Inc. Class A  COMMON           084670108    26586      300 SH       SOLE                    300        0        0
Brooks Automation, Inc.          COMMON           114340102     4047   323000 SH       SOLE                 323000        0        0
Central Securities Corporation   COMMON           155123102      620    26055 SH       SOLE                  26055        0        0
Costco Wholesale Corporation     COMMON           22160K105    34629   700000 SH       SOLE                 700000        0        0
Cisco Systems, Inc.              COMMON           17275R102    15408   900000 SH       SOLE                 900000        0        0
CEMEX, S.A. de C.V. ADR          COMMON           151290889    67817  1143041 SH       SOLE                1143041        0        0
Cytokinetics, Incorporated       COMMON           23282W100     3956   604900 SH       SOLE                 604900        0        0
Diageo plc                       COMMON           25243Q205    20405   350000 SH       SOLE                 350000        0        0
Dollar General Corporation       COMMON           256669102    14303   750000 SH       SOLE                 750000        0        0
Genentech, Inc.                  COMMON           368710406    30525   330000 SH       SOLE                 330000        0        0
Devon Energy Corporation         COMMON           25179M103    47405   758000 SH       SOLE                 758000        0        0
EMC Corporation                  COMMON           268648102     4086   300000 SH       SOLE                 300000        0        0
EMCORE Corporation               COMMON           290846104     1462   197000 SH       SOLE                 197000        0        0
EOG Resources, Inc.              COMMON           26875P101    44022   600000 SH       SOLE                 600000        0        0
Ethan Allen Interiors Inc.       COMMON           297602104    10046   275000 SH       SOLE                 275000        0        0
Golden West Financial            COMMON           381317106    38610   585000 SH       SOLE                 585000        0        0
Halliburton Company              COMMON           406216101    27262   440000 SH       SOLE                 440000        0        0
The Home Depot, Inc.             COMMON           437076102    68614  1695000 SH       SOLE                1695000        0        0
Lafarge North America Inc.       COMMON           505862102     9629   175000 SH       SOLE                 175000        0        0
Lamar Advertising Company        COMMON           512815101    16146   350000 SH       SOLE                 350000        0        0
Medtronic, Inc.                  COMMON           585055106    25907   450000 SH       SOLE                 450000        0        0
MedImmune, Inc.                  COMMON           584699102    14008   400000 SH       SOLE                 400000        0        0
MetLife, Inc.                    COMMON           59156R108    13965   285000 SH       SOLE                 285000        0        0
MFA Mortgage Investments, Inc.   COMMON           55272X102     7410  1300000 SH       SOLE                1300000        0        0
Molex Incorporated Class A       COMMON           608554200    13525   550000 SH       SOLE                 550000        0        0
Microsoft Corporation            COMMON           594918104    36610  1400000 SH       SOLE                1400000        0        0
M&T Bank Corporation             COMMON           55261F104    33806   310000 SH       SOLE                 310000        0        0
North Fork Bancorporation, Inc.  COMMON           659424105    16416   600000 SH       SOLE                 600000        0        0
Annaly Mortgage Management, Inc. COMMON           035710409     5470   500000 SH       SOLE                 500000        0        0
PepsiCo, Inc.                    COMMON           713448108    10339   175000 SH       SOLE                 175000        0        0
Pfizer Inc                       COMMON           717081103    29150  1250000 SH       SOLE                1250000        0        0
PartnerRe Ltd.                   COMMON           G6852T105    24626   375000 SH       SOLE                 375000        0        0
Patterson-UTI Energy, Inc.       COMMON           703481101    32950  1000000 SH       SOLE                1000000        0        0
Everest Re Group, Ltd.           COMMON           G3223R108    54189   540000 SH       SOLE                 540000        0        0
Republic Services, Inc.          COMMON           760759100    44121  1175000 SH       SOLE                1175000        0        0
Royce Value Trust                COMMON           780910105     2261   112611 SH       SOLE                 112611        0        0
SunTrust Banks, Inc.             COMMON           867914103    14552   200000 SH       SOLE                 200000        0        0
The TJX Companies, Inc.          COMMON           872540109    58075  2500000 SH       SOLE                2500000        0        0
Talisman Energy Inc.             COMMON           87425E103    52880  1000000 SH       SOLE                1000000        0        0
Total S.A. ADR                   COMMON           89151E109    41712   330000 SH       SOLE                 330000        0        0
Transatlantic Holdings, Inc.     COMMON           893521104    16800   250000 SH       SOLE                 250000        0        0
VeriSign, Inc.                   COMMON           92343E102     2924   133500 SH       SOLE                 133500        0        0
Weatherford International Ltd.   COMMON           G95089101    44164  1220000 SH       SOLE                1220000        0        0
Wal-Mart Stores, Inc.            COMMON           931142103    26910   575000 SH       SOLE                 575000        0        0
Xerox Corporation                COMMON           984121103    27835  1900000 SH       SOLE                1900000        0        0