Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Crowley John F
2. Date of Event Requiring Statement (Month/Day/Year)
05/30/2007
3. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD]
(Last)
(First)
(Middle)
C/O AMICUS THERAPEUTICS, INC., 6 CEDAR BROOK DRIVE
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President & CEO
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CRANBURY, NJ 08512
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 13,333 (1)
I
By MPAJ, LLC
Common Stock 60,000 (2)
I
By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 73,333 (3)
I
By John F. Crowley 2007 Grantor Retired Annuity Trust

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy)   (4) 01/06/2015 Common Stock 158,666 $ 0.638 D  
Employee Stock Option (right to buy)   (5) 08/17/2014 Common Stock 16,490 $ 0.638 D  
Employee Stock Option (right to buy)   (6) 10/20/2015 Common Stock 100,000 $ 5.33 D  
Employee Stock Option (right to buy)   (7) 02/28/2016 Common Stock 280,000 $ 5.33 D  
Employee Stock Option (right to buy)   (8) 04/25/2017 Common Stock 200,000 $ 13.43 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Crowley John F
C/O AMICUS THERAPEUTICS, INC.
6 CEDAR BROOK DRIVE
CRANBURY, NJ 08512
  X   X   President & CEO  

Signatures

/s/ Douglas A. Branch, Attorney-in-fact 05/30/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These shares are held by MPAJ, LLC.
(2) These shares are held by the Aileen A. Crowley 2007 Grantor Retained Annuity Trust. Mr. Crowley disclaims beneficial ownership of the shares held by the Aileen A. Crowley 2007 Grantor Retained Annuity Trust, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of section 16 or for any other purpose.
(3) These shares are held by the John F. Crowley 2007 Grantor Retained Annuity Trust.
(4) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on January 3, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 6,247 shares, beginning on February 3, 2006, with the final installment of 6,231 shares becoming exercisable on January 3, 2009.
(5) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on August 17, 2005. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 458 shares, beginning on September 1, 2005, with the final installment of 460 shares becoming exercisable on August 1, 2008.
(6) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on October 20, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 20,084 shares, beginning on November 1, 2006, with the final installment of 20,060 shares becoming exercisable on October 1, 2009.
(7) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vest on February 28, 2007. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 5,834 shares, beginning on March 1, 2007, with the final installment of 5,810 shares becoming exercisable on February 1, 2010.
(8) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on April 25, 2008. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 4,167 shares, beginning on May 1, 2008, with the final installment of 4,155 shares becoming exercisable on April 1, 2011.

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