(Name
of Issuer)
Common
Stock, par value $0.001 per share
|
||
(Title
of Class of Securities)
|
||
45168K108
|
||
(CUSIP
Number)
December
31, 2008
|
||
(Date
of Event which Requires Filing of this Statement)
|
CUSIP
No. 45168K108
|
|||
1
|
NAMES
OF REPORTING PERSONS
I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
Felix J.
Baker
|
||
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See
Instructions)
(a)
¨
(b)
¨
|
||
3
|
SEC
USE ONLY
|
||
4
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE
VOTING POWER
-0-
|
|
6
|
SHARED
VOTING POWER
2,174,210
|
||
7
|
SOLE
DISPOSITIVE POWER
-0-
|
||
8
|
SHARED
DISPOSITIVE POWER
2,174,210
|
||
9
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,174,210
|
||
10
|
CHECK BOX IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
(See
Instructions)
|
||
11
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.7%
|
||
12
|
TYPE
OF REPORTING PERSON (See Instructions)
IN
|
CUSIP
No. 45168K108
|
|||
1
|
NAMES
OF REPORTING PERSONS
I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
Julian C.
Baker
|
||
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See
Instructions)
(a)
¨
(b) ¨
|
||
3
|
SEC
USE ONLY
|
||
4
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE
VOTING POWER
-0-
|
|
6
|
SHARED
VOTING POWER
2,174,210
|
||
7
|
SOLE
DISPOSITIVE POWER
-0-
|
||
8
|
SHARED
DISPOSITIVE POWER
2,174,210
|
||
9
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,174,210
|
||
10
|
CHECK BOX IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
(See
Instructions)
|
||
11
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.7%
|
||
12
|
TYPE
OF REPORTING PERSON (See Instructions)
IN
|
Name
|
Business Address
|
Felix
J. Baker
|
667
Madison Avenue
New
York, NY 10065
|
Julian
C. Baker
|
667
Madison Avenue
New
York, NY 10065
|
Item
3.
|
If
this statement is filed pursuant to §§240.13d-1(b) or (c), check whether
the person filing is
a: N/A
|
Name
|
Number
of Shares
|
Percent
of Class
Outstanding
|
Baker
Bros. Investments, L.P.
|
52,763
|
0.2%
|
Baker
Bros. Investments II, L.P.
|
61,224
|
0.2%
|
667,
L.P
|
672,947
|
2.7%
|
Baker
Brothers Life Sciences, L.P.
|
1,345,283
|
5.4%
|
14159,
L.P.
|
41,417
|
0.2%
|
FBB
Associates
|
576
|
0.0%
|
________________________________
|
___________
|
_______
|
Total
|
2,174,210
|
8.7%
|
Item
7.
|
Identification
and Classification of the Subsidiary Which Acquired the Security Being
Reported on by the Parent Holding Company or Control
Person.
|
Item
8.
|
Identification
and Classification of Members of the
Group.
|
Item
9.
|
Notice
of Dissolution of Group.
|
Item
10.
|
Certification.
|
/s/
Felix J. Baker
|
Felix
J. Baker
|
/s/
Julian C. Baker
|
Julian
C. Baker
|
/s/
Felix J. Baker
|
Felix
J. Baker
|
/s/
Julian C. Baker
|
Julian
C. Baker
|