Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  InterWest Management Partners X, LLC
2. Date of Event Requiring Statement (Month/Day/Year)
06/27/2012
3. Issuer Name and Ticker or Trading Symbol
TESARO, Inc. [TSRO]
(Last)
(First)
(Middle)
2710 SAND HILL ROAD, SUITE 200
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

MENLO PARK, CA 94025
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series B Preferred Stock   (1)   (1) Common Stock 2,627,257 $ (1) D (2)  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
InterWest Management Partners X, LLC
2710 SAND HILL ROAD, SUITE 200
MENLO PARK, CA 94025
    X    
Rosch Thomas L
2710 SAND HILL ROAD, SUITE 200
MENLO PARK, CA 94025
    X    
Desai Keval
2710 SAND HILL ROAD, SUITE 200
MENLO PARK, CA 94025
    X    
NASR KHALED
2710 SAND HILL ROAD, SUITE 200
MENLO PARK, CA 94025
    X    

Signatures

/s/ W. Stephen Holmes, Managing Director 06/27/2012
**Signature of Reporting Person Date

/s/ Thomas L. Rosch by Karen A. Wilson Power of Attorney 06/27/2012
**Signature of Reporting Person Date

/s/ Keval Desai by Karen A. Wilson Power of Attorney 06/27/2012
**Signature of Reporting Person Date

/s/ Khaled A. Nasr by Karen A. Wilson Power of Attorney 06/27/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The reported securities are convertible at any time, in whole or in part, at the option of the holder, have no expiration date, and will convert into shares of common stock immediately prior to the closing of the Issuer's initial public offering.
(2) The shares are owned by InterWest Partners X, LP ("IW10"). InterWest Management Partners X, LLC ("IMP10") is the general partner of IW10. Harvey B. Cash, Bruce A. Cleveland, Christopher B. Ehrlich, Philip T. Gianos, W. Stephen Holmes, Nina S. Kjellson, Gilbert H. Kliman, Arnold L. Oronsky, Douglas A. Pepper and Thomas L. Rosch are managing directors of IMP10. Keval Desai and Khaled A. Nasr are venture members of IMP10. Each managing director and venture member of IMP10 disclaims beneficial ownership of such shares, except to the extent of their pecuniary interest therein.
 
Remarks:
Due to limitations of the EDGAR software, this Form 3 is filed on behalf of InterWest Management Partners X, LLC and certain other Reporting Persons, and is being filed on two Forms 3 (Part I and Part II) (collectively, the ''InterWest Form 3''). This filing represents Part II of the InterWest Form 3 and should be read together with Part I. Part I and Part II of the InterWest Form 3 shall constitute one filing. Exhibit List Exhibit 24.1- Power of Attorney of Thomas L. Rosch Exhibit 24.2- Power of Attorney of Keval Desai Exhibit 24.3- Power of Attorney of Khaled A. Nasr Exhibit 99 - Form 3 Joint Filer Information

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

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